Publications
Du, D. X., Simjanoska, M., Fitzpatrick, A. W. P. Four-dimensional microED of conformational dynamics in protein microcrystals on the femto-to-microsecond timescales. Journal of structural biology, 215(1), 107941. March 2023
Beenken, A., Cerutti, G., Brasch, J., Guo, Y., Sheng, Z., Erdjument-Bromage, H., Aziz, Z., Robbins-Juarez, S. Y., Chavez, E. Y., Ahlsen, G., Katsamba, P. S., Neubert, T. A., Fitzpatrick, A. W. P., Barasch, J., & Shapiro, L.. Structures of LRP2 reveal a molecular machine for endocytosis. Cell, 186(4), 821–836.e13. February 2023
Du, D. X., Fitzpatrick, A. W. P. Design of an ultrafast pulsed ponderomotive phase plate for cryo-electron tomography. Cell reports methods, 3(1), 100387. January 2023
Andrew Chang*, Xinyu Xiang*, Jing Wang*, Carolyn Lee*, Tamta Arakhamia*, Marija Simjanoska*, Chi Wang, Yari Carlomagno, Guoan Zhang, Shikhar Dhingra, Manon Thierry, Jolien Perneel, Bavo Heeman, Lauren M. Forgrave, Michael DeTure, Mari L. DeMarco, Casey N. Cook, Rosa Rademakers, A.W.P. Fitzpatrick. *These authors contributed equally to this work. Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases. Cell. 185 (8), 1346-1355. e15 April 2022
Carlomagno, Y., Manne, S., DeTure, M., Prudencio, M., Zhang, Y. J., Hanna Al-Shaikh, R., Dunmore, J. A., Daughrity, L. M., Song, Y., Castanedes-Casey, M., Lewis-Tuffin, L. J., Nicholson, K. A., Wszolek, Z. K., Dickson, D. W., Fitzpatrick, A. W. P., Petrucelli, L., & Cook, C. N. (2021). The AD tau core spontaneously self-assembles and recruits full-length tau to filaments. Cell reports. 34(11), 108843. March 16, 2021
T. Arakhamia*, C.E. Lee*, Y. Carlomagno*, D.M. Duong, S.R. Kundinger, K. Wang, D. Williams, M. DeTure, D.W. Dickson, C.N. Cook, N.T. Seyfried, L. Petrucelli, A.W.P. Fitzpatrick. *These authors contributed equally to this work. Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains. Cell. 180 (4), 633-644. e12. February 2020
A.W.P. Fitzpatrick, B. Falcon, S. He, G.N. Murshudov, A.G. Murzin, H.J. Garringer, R.A. Crowther, B. Ghetti, M. Goedert, S.H.W. Scheres. Cryo-EM structures of tau filaments from Alzheimer's disease. Nature. 547(7662):185-190. July 2017
Ho, C. M., Li, X., Lai, M., Terwilliger, T. C., Beck, J. R., Wohlschlegel, J., Goldberg, D. E., Fitzpatrick, A. W. P., & Zhou, Z. H. Bottom-up structural proteomics: cryoEM of protein complexes enriched from the cellular milieu. Nature methods, 17(1), 79–85. January 2020
A.W.P. Fitzpatrick, H. R. Saibil. Cryo-EM of amyloid fibrils and cellular aggregates. Current Opinion in Structural Biology. 58:34-42. October 2019
A.W.P. Fitzpatrick*, S. Llabrés, A. Neuberger, J. N. Blaza, X. C. Bai, U. Okada, S. Murakami, H. W. van Veen, U. Zachariae, S. H. W. Scheres, B. F. Luisi, D. Du*. *These authors contributed equally to this work. Structure of an ABC-type tripartite multidrug efflux pump. Nature Microbiology. 2:17070. May 2017
G.M. Vanacore, A.W.P. Fitzpatrick, A.H. Zewail. 4D electron microscopy: from materials science to biology. Nano Today. 11(2):228-249. April 2016
A.W.P. Fitzpatrick, G.M. Vanacore, A.H. Zewail. Nanomechanics and intermolecular forces of amyloid. Proceedings of the National Academy of Sciences. 112(11):3380-85. March 2015
G.T. Debelouchina, M.J. Bayro, A.W.P. Fitzpatrick, V. Ladizhansky, M. Colvin, M.A. Caporini, C.P. Jaroniec, V.S. Bajaj, M. Rosay, C.E. MacPhee, M. Vendruscolo, W. Maas, C.M. Dobson, R.G. Griffin. Higher order amyloid fibril structure by MAS NMR and DNP. Journal of American Chemical Society. 135(51):19237-47. December 2013
A.W.P. Fitzpatrick, U.J. Lorenz, G.M. Vanacore, A.H. Zewail. 4D cryo-electron microscopy of proteins. Journal of the American Chemical Society. 135(51):19123-26. December 2013
A.W.P. Fitzpatrick, S.T. Park, A.H. Zewail. Exceptional rigidity and biomechanics of amyloid revealed by 4D electron microscopy. Proceedings of the National Academy of Sciences. 110(27):10976-81. June 2013
A.W.P. Fitzpatrick, G.T. Debelouchina, M.J. Bayro, D.K. Clare, M.A. Caporini, V.S. Bajaj, C.P. Jaroniec, L. Wang, V. Ladizhansky, S.A. Müller, C.E. Macphee, C.A. Waudby, H.R. Mott, A. De Simone, T.P.J. Knowles, H.R. Saibil, M. Vendruscolo, E.V. Orlova, R. Atomic structure and hierarchical assembly of a cross-β amyloid fibril. Proceedings of the National Academy of Sciences. 110(14):5468-73. March 2013
C.A. Waudby, C.Camilloni, A.W.P. Fitzpatrick, L.D. Cabrita, C.M. Dobson, M. Vendruscolo, J. Christodoulou. In-cell NMR characterization of the secondary structure populations of a disordered conformation of α-synuclein within E. coli cells. PLoS One. 8(8):e72286. January 2013
T.P.J. Knowles, A. De Simone, A.W.P. Fitzpatrick, A.J. Baldwin, S. Meehan, L. Rajah, M. Vendruscolo, M.E. Welland, C.M. Dobson, E.M. Terentjev. Twisting transition between crystalline and fibrillar phases of aggregated peptides. Physical Review Letters. 109(15):158101. October 2012
A.W.P. Fitzpatrick, T.P.J. Knowles, C.A. Waudby, M. Vendruscolo, C.M. Dobson. Inversion of the balance between hydrophobic and hydrogen bonding interactions in protein folding and aggregation. PLoS Computational Biology. 7(10):e1002169. October 2011
A.J. Baldwin, T.P.J. Knowles, G.G. Tartaglia, A.W.P. Fitzpatrick, G.L. Devlin, S.L. Shammas, C.A. Waudby, M.F. Mossuto, S. Meehan, S.L. Gras, J. Christodoulou, S.J. Anthony-Cahill, P.D. Barker, M. Vendruscolo, C.M. Dobson. Metastability of native proteins and the phenomenon of amyloid formation. Journal of American Chemical Society. 133(36):14160-3. June 2011
M.A. Caporini, V.S. Bajaj, M. Veshtort, A.W.P. Fitzpatrick, C.E. MacPhee, M. Vendruscolo, C.M. Dobson, R.G. Griffin. Accurate Determination of Interstrand Distances and Alignment in Amyloid Fibrils by Magic Angle Spinning NMR. The Journal of Physical Chemistry B. 114(42). October 2010
B. Strodel, A.W.P. Fitzpatrick, M. Vendruscolo, C.M. Dobson, D.J. Wales. Characterizing the first steps of amyloid formation for the ccbeta peptide.The Journal of Physical Chemistry B. 112(32):9998-10004. August 2008
T.P. Knowles*, A.W.P. Fitzpatrick*, S. Meehan, H.R. Mott, M. Vendruscolo, C.M. Dobson. *These authors contributed equally to this work. Role of intermolecular forces in defining material properties of protein nanofibrils. Science. 318(5858):1900-3. January 2008